He remained in Park Hill, where he married again in 1842, to Erminia Nash. Worcester worked tirelessly to help resolve the differences between the Georgia Cherokee and the "Old Settlers", some of whom had relocated there in the late 1820s. On April 20, 1859, he died in Park Hill, Indian Territory.

Missionary to the Cherokee Indians. Born in Massachusetts, Worcester graduated from the University of Vermont (1819) and Andover Theological Seminary (1823). He was ordained a Congregationalist minister in 1825 and was appointed the same year to a mission station in eastern Tennessee.

Georgia state authorities arrested Worcester and several other missionaries. After they were convicted at trial in 1831 and sentenced to four years of hard labour in prison, Worcester appealed to the U.S. Supreme Court. Worcester argued that Georgia had no right to extend its laws to Cherokee territory.